CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. View abstract. View abstract. Intern Med 2007;46:575-8. Sato H, Goto W, Yamamura J, et al. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Au, T. K., Lam, T. L., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. The U.S. Food and Drug . Arch.Pharm Res 2012;35(11):1945-1952. View abstract. View abstract. How Much Is Too Much? View abstract. Licorice might decrease how well cisplatin works. J Cardiovasc.Surg (Torino) 2000;41(4):631-632. 2020;16(3):458-462. Lin, J. C. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. Report of 2 cases and review of the literature. View abstract. Murck H, Lehr L, Hahn J, Braunisch MC, Jezova D, Zavorotnyy M. Adjunct Therapy With Glycyrrhiza Glabra Rapidly Improves Outcome in Depression-A Pilot Study to Support 11-Beta-Hydroxysteroid Dehydrogenase Type 2 Inhibition as a New Target. View abstract. [Clinical study on effect of recombinant roasted licorice decoction combined with low-dose glucocorticoids in treating idiopathic thrombocytopenic purpura]. Liquorice and hypertension. The dogs treated with the herbal mixture saw a 37.5 percent improvement . View abstract. Harada M, Suzuki M, Ozaki Y. View abstract. Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption. Hattori, M., Sakamoto, T., Kobashi, K., and Namba, T. Metabolism of glycyrrhizin by human intestinal flora. Aoki, F., Nakagawa, K., Kitano, M., Ikematsu, H., Nakamura, K., Yokota, S., Tominaga, Y., Arai, N., and Mae, T. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. This information may not fit your specific health circumstances. The anti-estrogenic action of beta-glycyrrhetinic acid. Endocrinol Jpn 1990;37:331-41. View abstract. Am.J Chin Med 2004;32(4):569-578. Anonymous. View abstract. Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S., and Yamamoto, N. Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV- III/LAV)]. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. Lancet 1992;340:13-17. Taking too much licorice can cause high blood pressure. View abstract. Diane Calello, executive medical director of the New Jersey Poison Control Center, based at Rutgers New Jersey Medical School, discusses safe . A 2020 review found that licorice root extract can help reduce the growth of . View abstract. In an ovarietctomized model, oral administration of a combination of white peony and licorice increased DHEA and serum estrogen concentration. Lin SH, Yang SS, Chau T, Halperin ML. Liang Xiao, Wang YZ, Jing Liu, et al. Zangooei Pourfard M, Mirmoosavi SJ, Beiraghi Toosi M, et al. Efficacy and tolerability of hydroalcoholic extract of Paeonia officinalis in children with intractable epilepsy: An open-label pilot study. Xu, L., Jiang, J., and Du, F. Z. Reuter, J., Merfort, I., and Schempp, C. M. Botanicals in dermatology: an evidence-based review. View abstract. View abstract. Purnak, T., Ozaslan, E., Beyazit, Y., and Haznedaroglu, I. C. Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. Lancet 2000;355(9198):134-138. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. Since the content of glycyrrhizin is either decreased or removed from the DGL licorice supplement, its positive effects on PCOS may also be reduced. Part 2: Effect of glycyrrhizic acid on the course of illness]. View abstract. The benefits of licorice root can be enjoyed as a tea, supplement, tincture, or topical treatment, and even as candies. Note: Results may vary from person to person, depending on the skin type. Gatica-Ortega ME, Pastor-Nieto MA. View abstract. The chemicals in licorice are thought to . View abstract. Z., Zhang, Y. J Endocrinol Invest 1996;19:624-9. Case Rep Emerg Med. Birth outcome in relation to licorice consumption during pregnancy. Sontia B, Mooney J, Gaudet L, Touyz RM. View abstract. Clin Exp Obstet Gynecol 2013;40(1):141-143. Anesth Analg 2009;109(1):77-81. It contains kojic acid, witch hazel, and licorice extracts that reduce melanin production and exfoliate . Licorice is available in many different types of products, including candies, lozenges, teas, chewing, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Side effects in people after breathing tube removal. Ann Mtg Digestive Disease Week 1999 May. A botanical dietary supplement from white peony and licorice attenuates nonalcoholic fatty liver disease by modulating microbiota and reducing inflammation . View abstract. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. View abstract. White Peony Tea Side Effects. View abstract. O'Connell K, Kinsella J, McMahon C, Holian J, O'Riordan S. Posterior reversible encephalopathy syndrome (PRES) associated with liquorice consumption. Low potassium levels can increase the side effects of digoxin. View abstract. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. View abstract. View abstract. Kase Y, Saitoh K, Ishige A, et al. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. 2019;38(3):657-64. View abstract. Phytother Res 1988;2(3):140-145. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Biol Pharm Bull 2000;23:199-203.. View abstract. Scali, M., Pratesi, C., Zennaro, M. C., Zampollo, V., and Armanini, D. Pseudohyperaldosteronism from liquorice-containing laxatives. Armanini D, Lewicka S, Pratesi C, et al. Hinoshita F, Ogura Y, Suzuki Y, et al. Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. 2016 Oct;39:314-319. doi: 10.1016/j.intimp.2016.08.006. Clinical and immunological consequences of total glucosides of paeony treatment in Sjgren's syndrome: A randomized controlled pilot trial. Yu IC, Tsai YF, Fang JT, Yeh MM, Fang JY, Liu CY. View abstract. View abstract. Contact Dermatitis 1999;40(1):56. Yamaguchi, H., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., and Ryoyama, K. Glycyrrhetinic acid induces anoikis-like death and cytoskeletal disruption in the central nervous system tumorigenic cells. Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Wang H, Dong L, Qu F, et al. 2003;84(1):85-89. Pak J Med Sci 2022;38(1):271-275. Am J Clin Dermatol 2010;11(4):247-267. Nahidi F, Zare E, Mojab F, Alavi-Majd H. Effects of licorice on relief and recurrence of menopausal hot flashes. View abstract. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. View abstract. An open study of 100 women with uterine fibroids showed that peony reduced the size of . Beretta-Piccoli, C., Salvade, G., Crivelli, P. L., and Weidmann, P. Body-sodium and blood volume in a patient with licorice-induced hypertension. Melzer J, Rosch W, Reichling J, et al. J Clin Psychopharmacol 2008;28(3):264-370. Hossain, M. S., Takimoto, H., Hamano, S., Yoshida, H., Ninomiya, T., Minamishima, Y., Kimura, G., and Nomoto, K. Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection. Wang H, Wei W, Wang NP, et al. A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. Z Kardiol 1991;80(6):389-391. J Altern Complement Med 2010;16(10):1065-1071. Int J Environ Res Public Health 2021;19(1):242. Int J Dermatol 1999;38:387-92 . Proanthocyanidins, flavonoids, tannins, polysaccharides, and paeoniflorin are all considered to contribute to the medicinal activity of various forms of peony. Nat Prod Res 2007;21(14):1234-1241. Case 30-2020: A 54-Year-Old Man with Sudden Cardiac Arrest. J Agric Food Chem 6-13-2007;55(12):4691-4697. The efficacy of an ayurvedic preparation of yashtimadhu (Glycyrrhiza glabra) on radiation-induced mucositis in head-and-neck cancer patients: A pilot study. It's thought liquorice's side-effects are caused by the glycyrrhizic acid, but it is possible to buy deglycyrrhizinated liquorice (DGL), which may help prevent these issues. Early evidence suggests that taking 45 grams of a specific product containing peony and licorice (Peony-Glycyrrhiza Decoction, PGD) daily for 4 weeks reduces levels of a hormone called prolactin in women with high levels of prolactin, without affecting other hormone levels or mental symptoms. Effects of chalcones isolated from licorice roots on leukotriene biosynthesis in human polymorphonuclear neutrophils. We currently have no information for PEONY overview. Fan ZJ, Liu JM, Li XX, et al. J Steroid Biochem Mol Biol 1994;49:81-5. Astragalus may be safe when used orally and appropriately. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. But I didn't take it long enough to see any change. View abstract. Deglycyrrhizinated liquorice in aphthous ulcers. Nephron 2002;90:240. Dobbins, K. R. and Saul, R. F. Transient visual loss after licorice ingestion. View abstract. 1993;13(10):591-3, 579. View abstract. View abstract. Ir J Med Sci 2016;185(4):945-7. Gardner Z, McGuffin M. Boca Raton, FL: CRC Press, 2013. Muscle cramps.Early research suggests that taking a specific combination of peony and licorice (Shakuyaku-kanzoh-to) might ease muscle cramps in people with liver cirrhosis and in people undergoing hemodialysis. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Papandreou V, Magiatis P, Chinou I, et al. Menopause 2002;9:145-50. View abstract. Previous studies have estimated that a dose of 1 to 5 grams (g) of licorice root daily is safe for most adults. Hataya Y, Oba A, Yamashita T, Komatsu Y. Hyponatremia in an elderly patient due to isolated hypoaldosteronism occurring after licorice withdrawal. Pakravan F, Salehabad NH, Karimi F, Isfahani MN. Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. 1986;6(12):714-6, 707. Postgrad Med J 2003;79:115-6.. View abstract. Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG. View abstract. Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis. Ann Clin Biochem 2007;44(Pt 4):397-399. Rev Med Brux 2008;29(5):490-493. Licorice is an herb that grows in parts of Europe and Asia. Burgess, J. J Clin Hypertens (Greenwich) 2008;10:153-7. Int Endod.J 2011;44(1):51-58. QJM 2011;104(12):1093-1095. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Some possible side effects with oral use include rash, itching, nasal symptoms, or stomach discomfort, but these are uncommon. Life Sci 2005;78:413-20 . Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Monitor your blood pressure closely. J Clin Hypertens (Greenwich) 2016;18(2):159-60. An Med Interna 1995;12(1):33-35. and its bioactive compounds. View abstract. Celik, M. M., Karakus, A., Zeren, C., Demir, M., Bayarogullari, H., Duru, M., and Al, M. Licorice induced hypokalemia, edema, and thrombocytopenia. Results of a double-blind placebo controlled comparative study]. Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Madisch A, Holtmann G, Mayr G, et al. Biomed.Chromatogr. View abstract. View abstract. Brasseur, A. and Ducobu, J. Lipids Health Dis 2011;10:29. BMJ Case Rep. 2012 Oct 19;2012. Z Gastroenterol 2001;39(7):511-7. Complement Ther Med. View abstract. Awad N, Makar G, Burroughs V, Ravi P, Burroughs SR. Licorice-induced apparent mineralocorticoid excess causing persistent hypertension and hypokalemia. Kitagawa, I., Chen, W. Z., Hori, K., Harada, E., Yasuda, N., Yoshikawa, M., and Ren, J. Severe hypokalaemia with paralysis induced by small doses of liquorice. J Dermatolog Treat 2003;14(3):153-157. A. and Cunliffe, W. J. Self-medication with liquorice in a patient with Addison's disease. Kent UM, Aviram M, Rosenblat M, Hollenberg PF. View abstract. Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism. View abstract. OTHER NAME(S): Bai Shao, Chi Shao, Chinese Peony, Common Peony, C. Peony (Paeonia lactiflora) is an herb. View abstract. Wang W, Tian DD, Zheng B, et al. View abstract. J Cancer Res Ther. View abstract. View abstract. 6 Top Celery Juice Benefits & Side Effects. View abstract. Am J Chin Med 1996;24:165-8. [Protective mechanism of Salvia miltiorrhiza and Paeonia lactiflora for experimental liver damage]. View abstract. Licorice, tobacco chewing, and hypertension. Eisenburg, J. J Peripher.Nerv.Syst. Effect of orally administered shao-yao-gan-cao-tang (Shakuyaku-kanzo-to) on muscle cramps in maintenance hemodialysis patients: a preliminary study. Lancet 1990;335(8697):1060-3. View abstract. Severe hypokalemic paralysis and rhabdomyolysis due to ingestion of liquorice. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Doeker, B. M. and Andler, W. Liquorice, growth retardation and Addison's disease. Eur J Dermatol. Riv Patol Nerv Ment 1983;104(4):179-183. View abstract. A comparison of carbenoxolone sodium and deglycyrrhizinated liquorice in the treatment of gastric ulcer in the ambulant patient. Clin Neurol Neurosurg 2003;105:286-7.. View abstract. A., van Dokkum, W., and Savelkoul, T. J. Glycyrrhizic acid: the assessment of a no effect level. 5-10-2004;208(1):89-94. View abstract. Ohta H, Ni JW, Matsumoto K, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. Sheth, V. M. and Pandya, A. G. Melasma: a comprehensive update: part II. Chem Pharm Bull (Tokyo) 1994;42(5):1056-1062. Am J Nephrol 2000;20:145-8. Holtmann G, Madisch A, Juergen H, et al. J Cosmet.Sci 2006;57(1):57-64. Although white peony is generally considered safe for most people, drinking large amounts might have some negative consequences. Peony might block chemicals that can cause pain and swelling . A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. Rackova, L., Jancinova, V., Petrikova, M., Drabikova, K., Nosal, R., Stefek, M., Kostalova, D., Pronayova, N., and Kovacova, M. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin. The Potential Benefits and Side Effects of the White Peony Root. Westman EC, Guthrie GP. Takahara T, Watanabe A, Shiraki K. Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. View abstract. Practitioner 1973;210:820-3. 1991;11(4):199-202, 195. Planta Med 1983;48(5):38-42. 2013 Sep;117(3):614-21. This week, The New England Journal of Medicine reported that a man with a poor diet died of cardiac arrest after eating a bag-and-a-half of black licorice daily for weeks. View abstract. Biol Pharm Bull. Clin Rheumatol. View abstract. Report of a new case]. [The nature of an anticoagulant isolated from peonies in the central zone of Russia]. View abstract. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. Mayo Clin Proc 2003;78:767-8. View abstract. Phytother Res. van Rossum, T. G., Vulto, A. G., Hop, W. C., Brouwer, J. T., Niesters, H. G., and Schalm, S. W. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. WebMD does not provide medical advice, diagnosis or treatment. Schweiz Med Wochenschr 2-26-1977;107(8):276-279. The sweet cake that reaches parts other cakes can't! View abstract. Effect of shakuyaku-kanzoh-toh, a prescription composed of shakuyaku (Paeoniae Radix) and kanzoh (Glycyrrhizae Radix) on guinea pig ileum. Bell ZW, Canale RE, Bloomer RJ. A. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. Guo, T. L. and Zhou, X. W. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Ann Pharmacother 2003;37(6):836-838. View abstract. View abstract. Some medications are changed and broken down by the liver. "Water pills" can also decrease potassium levels. They also have a range of other intriguing activities. World J Gastroenterol 2-7-2006;12(5):760-764. No negative side effects. Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report. View abstract. Licorice root extract is often used to relieve symptoms of indigestion, such as acid reflux, upset stomach, and heartburn. 44 ($0.09/Count) NEW PACKAGING White Peony Root Bai Shao 4oz 38. . View abstract. Licorice can decrease potassium levels. 2008;9(3):88-98. Peony might have some of the same effects as estrogen. Deglycyrrhizinated liquorice in duodenal ulcer. Mol.Nutr Food Res 2011;55(2):318-327. Phytomedicine 2003;10:271-85. View abstract. Saw palmetto. Cotterill, J. Kim, H. J., Chang, E. J., Bae, S. J., Shim, S. M., Park, H. D., Rhee, C. H., Park, J. H., and Choi, S. W. Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora. [Paeonia Lactiflora injection in treating chronic cor pulmonale with pulmonary hypertension]. Licorice is Sita (cold) in nature, Guru (heavy) to digest, and Madhura (sweet) in . View abstract. View abstract. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. A double-blind, randomized, placebo-controlled, multicenter trial. A Rutgers expert discusses how eating black licorice can affect your health. Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Hepatology 1997;25(6):1390-1397. Chinese peony root comes in two different forms. Effects of total glucosides of peony on immunological hepatic fibrosis in rats. Therapeutic Research Faculty 2020. View abstract. After lab testing, the Cheng team found that Huang Qin Tang had a high inhibitory property against the debilitating side effects of a chemotherapy drug called CPT-11 (later approved as irinotecan), including diarrhea, nausea, and vomiting. BMJ Case Rep. 2013 Sep 19;2013. Immunology 1997;90(1):115-120. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. For people who already have high blood pressure or heart or kidney disease, as little as 5 g/day can cause these side effects. View abstract. Objective: To evaluate the effect of different ratio of peony and licorice and Christina Loosestrife herb decoction on isolated in New Zealand . View abstract. View abstract. Dying for a cup of tea. Curr.Pharm.Des 2010;16(26):2935-2947. 2014 Jun;20(6):516-20. Ngan LT, Moon JK, Shibamoto T, Ahn YJ. J Hum Hypertens 2001;15:549-52. Kraus SD, Kaminskis A. Isr J Dent Sci 1989;2(3):153-157. Eur J Drug Metab Pharmacokinet. View abstract. Morris DJ, Davis E, Latif SA. View abstract. J Hepatol 1994;21:601-9. Let's take a look at the forms, uses, and side effects of . View abstract. View abstract. View abstract. View abstract. Phytother Res 2012;26(9):1381-1384. Strandberg TE, Jarvenpaa AL, Vanhanen H, McKeigue PM. Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection: a randomized, double-blind, placebo-controlled study. View abstract. Chamberlain, J. J. and Abolnik, I. Lee, I. T., Lee, W. J., Tsai, C. M., Su, I. J., Yen, H. T., and Sheu, W. H. Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome. Phytotherapy Research 1997;11:207-210. van Gelderen, C. E., Bijlsma, J. The author has an hindex of 4, co-authored 18 publication(s) receiving 46 citation(s). Brouwers, A. J. and van der, Meulen J. View abstract. Licorice might increase how quickly midazolam is broken down by the body. View abstract. Liu J. Fuhrman, B., Volkova, N., Kaplan, M., Presser, D., Attias, J., Hayek, T., and Aviram, M. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. View abstract. Other side effects of licorice use include . Black licorice can have serious side effects when eaten in large amounts. Murakami, T. and Uchikawa, T. Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. View abstract. J Med Liban 2012;60(2):117-119. Pharmazie 2010;65(8):624-8. View abstract. Postgrad Med J 1980;56(657):526-529. Dong quai grows at high altitudes in the cold, damp, mountains of China, Korea, and Japan. Braz J Infect Dis 2016;20(6):534-8. Effect of orally administered shao-yao-gan-cao-tang (Shakuyaku-kanzo-to) on muscle cramps in maintenance hemodialysis patients: a preliminary study. Phytother Res 2008;22:563-5. J Nat Prod 1980;43(2):259-269. White peony ( bai shao in Chinese) is root without any bark, while red peony . Gibertoni, M., Bonito, V., Colombo, A., Falasca, A., and Nichelli, P. [Licorice-induced myopathy. Tewari SN, Wilson AK. Suzuki H, Ohta Y, Takino T, and et al. . Abe Y, Ueda T, Kato T, Kohli Y. Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A. Epilepsy Res 2021;176:106735. View abstract. View abstract. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. Kumada T, et al. "It contains liquiritin, an active compound that helps to disperse and remove existing melanin in the skin," explains Chwalek. Nutrition 2002;18(3):268-273. Zhong.Xi.Yi.Jie.He.Za Zhi. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. A., Motallebnejad, M., and Khanian, M. The efficacy of the bioadhesive patches containing licorice extract in the management of recurrent aphthous stomatitis. (Tokyo) 2008;54(3):244-249. View abstract. Effect of licorice on reduction of body fat mass in healthy subjects. View abstract. Licorice might decrease how quickly the body breaks down methotrexate. View abstract. Effect of glycyrrhizin on viral replication and quasispecies in patients with type C chronic hepatitis. Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo. Zong, P. P., Yan, T. Y., and Gong, M. M. [Clinical and experimental studies of effects of huayu decoction on scavenging free radicals]. 2013 Jun;22(2):173-8. Engqvist, A., von Feilitzen, F., Pyk, E., and Reichard, H. Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. View abstract. 2000;19(8):434-439. Ai, M., Yamaguchi, T., Odaka, T., Mitsuhashi, K., Shishido, T., Yan, J., Seza, A., and Saisho, H. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. J Clin Psychopharmacol 1997;17(3):234-235. View abstract. J Am Coll.Nutr 2007;26(3):209-218. View abstract. This plant is native to East Asia. The effect of Glycyrrhiza glabra L. on primary dysmenorrhea compared with ibuprofen: A randomized, triple-blind controlled trial. 2013 Nov;18(6):593-6. View abstract. Rees, W. D., Rhodes, J., Wright, J. E., Stamford, L. F., and Bennett, A. Taking peony along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Not too many side effects of peony tea that we need to worry about.
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